metadata: {"signature": "0x6971a62e82dc1eb21c1ee3e7b8d00e395ccf5e6e7a7a8ffb067161196ae8f4e377fc74e41d802af9bb20bf2c8e393705c1dafb291b990e783556c81f60e66d351c", "application": {"round": "0x7b150594d8d758bcb2c3f855ffab3ece27ad2983", "answers": [{"type": "email", "hidden": true, "question": "Email Address", "questionId": 0, "encryptedAnswer": {"ciphertext": "qH/H5nDBGEUWe6JUIyr9v9jrpxnkW1KSRa8ZhMHpcXBL7FISlVlg9d4xq0XSw37i", "encryptedSymmetricKey": "acea4be856cb48d03fd4a75b176409ca06e35be5250bf9f990b6d89a84cb7644223d357b8f73fd3c96fafe3d48a84b04079a6b914f5604d60ce94f74d1c23f20451969722a150a8678e146ecfd45c71e2d11f373c4d9a5e7a3d35ec53d9a2ea33e557a6f9045a88ccec2a995c83773423293aa431571b76eb334eb3957d569910000000000000020740b9ba9700c4bc8f7ba623cc7b0c1d1f1e2f210fbfd559b23f186aa8141c9899ecc2eb216f6945a6ac73844b77f3ca7"}}, {"type": "short-answer", "answer": "n/a", "hidden": false, "question": "Funding Sources", "questionId": 1}, {"type": "number", "answer": "1", "hidden": false, "question": "Team Size", "questionId": 2}, {"type": "short-answer", "answer": "raimbetov", "hidden": true, "question": "Telegram username", "questionId": 3}, {"type": "paragraph", "answer": "<100 USD", "hidden": true, "question": "Total prior funding for project in USD", "questionId": 4}, {"type": "paragraph", "answer": "https://twitter.com/r_aimbetov\nhttps://www.linkedin.com/in/raimbetov/", "hidden": true, "question": "Profiles or socials of other main team members publicly associated with project", "questionId": 5}, {"type": "paragraph", "answer": "6", "hidden": true, "question": "How old is the project? (Months)", "questionId": 6}, {"type": "paragraph", "answer": "# Summary\nThe **Spacefarer Phenome** is the concept of an optimized collection of human phenotypic traits, dictated by genetics, that are specifically adapted for the rigors of space exploration and life in extraterrestrial environments. It encompasses the idea of identifying or engineering these traits to enhance human resilience against space-related challenges, such as increased radiation, microgravity, and isolation, aiming to improve the feasibility and sustainability of long-duration space missions and off-world colonization.\n\n# Problem\nAs humanity aspires to explore and settle in space, we encounter unique challenges, such as harmful radiation, microgravity, and psychological stress, that impact human health and longevity. Traditional space missions have highlighted these issues, but the ambitious goal of colonization demands innovative solutions to ensure human survival and well-being in space.\n\nHuman physiology is not naturally suited to the harsh conditions of space, leading to accelerated aging, muscle wasting, bone loss, and psychological challenges. These factors severely limit the feasibility of long-duration space missions and the dream of colonizing other planets. Without addressing these challenges, the future of human space exploration and settlement remains uncertain.\n\n# Solution\nThe **Spacefarer Phenome** is a visionary solution that focuses on identifying and engineering genetic traits that enhance human capabilities for space exploration. By leveraging advancements in genomics, biotechnology, and longevity research, this concept aims to develop a human phenotype optimized for space environments, ensuring individuals are better equipped to withstand the rigors of space travel and life on other worlds.", "hidden": false, "question": "Describe your project in a few paragraphs (ideally including a problem statement, solution, roadmap, and timeline for implementation)", "questionId": 7}, {"type": "paragraph", "answer": "The project is a collaboration between [Overlake Biologics](https://overlake.bio/), a DeSci longevity research and development initiative, and [PoSciDonDAO](https://www.poscidondao.com/), a decentralized autonomous organization dedicated to funding research in personalized medicine. The project aims to foster decentralized, open-source hard science to address blind spots in the current scientific narrative.", "hidden": false, "question": "How does your project support the mission or goals of DeSci?", "questionId": 8}, {"type": "paragraph", "answer": "# Scientific goals\n- List and annotate traits conducive to space exploration, such as efficient DNA repair, increased muscle mass and quality, robust circadian cycles, and cardiovascular health.\n- Link these traits to genetic polymorphisms, gene expression signatures, and their associated regulatory contexts to identify biological nodes for future interventions.\n- Survey these nodes for druggable targets and explore existing therapies for potential repurposing.\n- Map the therapeutic efficacy of existing drugs to individual genomic profiles to develop personalization strategies.\n\n# Community goals\n- Develop collaboration across the DeSci ecosystem to attract expertise.\n- Promote understanding of the biological challenges of space travel and the necessity for personalized interventions to make space accessible to everyone.", "hidden": false, "question": "Describe how funds from the grants program will be used for your project.", "questionId": 9}, {"type": "paragraph", "hidden": true, "question": "If you participated in past grant rounds (i.e. DeSci GR15/ Beta) using a different project payout wallet address, please share it here.", "questionId": 10}, {"type": "paragraph", "answer": "n/a", "hidden": false, "question": "If this project participated in past DeSci grant rounds, please share any new updates or milestones since the last round.", "questionId": 11}, {"type": "paragraph", "answer": "", "hidden": true, "question": "Is there any other information you would like to share about your project, previous work, other project affiliations, or potential conflicts of interest? (or anything not covered elsewhere in this application that you feel is relevant to share)", "questionId": 12}, {"type": "dropdown", "answer": "Yes", "hidden": false, "question": "Does 50% of your team reflect the diversity of the community your project serves with a particular emphasis on including women, Black, Indigenous, and People of Color (BIPoC), individuals with disabilities, and members of the LGBTQ+ community?", "questionId": 13}, {"type": "multiple-choice", "answer": "Hateful Content - No racist, sexist, or otherwise hateful speech, no discrimination", "hidden": true, "question": "Please read the following exclusion criteria that are not permitted and will result in rejection or removal from the round.", "questionId": 14}], "project": {"id": "0x091160c25279e519afa3f181c4dcbee84ebbb72e2c4f9a4de7af586d5a4bb5c0", "title": "Spacefarer phenome", "logoImg": "bafkreicv2gxwce6mglwdwc67wdj65bolsqsteya5bi46impndp7lw7mfli", "metaPtr": {"pointer": "bafkreic5ngrgxtg5bxxmlfo5wbuhx7jalbhmpoeolgu6tvicbdr3uhmqqi", "protocol": "undefined"}, "website": "https://overlake.bio/", "bannerImg": "bafkreiemcpbtkl66clokbbbtwcxqejawh37y64jjrjpy26uf74dhvu3rdm", "createdAt": 1714163052493, "credentials": {"twitter": {"type": ["VerifiableCredential"], "proof": {"jws": "eyJhbGciOiJFZERTQSIsImNyaXQiOlsiYjY0Il0sImI2NCI6ZmFsc2V9..3PU57g__kibYGXmv6SjLCrfvj37apkQkKwEvkvPk0Oj_5nFDywa7IF1-L2BTBRxIyf_3Y2nG54GC3wRxJuLSCA", "type": "Ed25519Signature2018", "created": "2024-04-26T20:20:15.256Z", "proofPurpose": "assertionMethod", "verificationMethod": "did:key:z6MkghvGHLobLEdj1bgRLhS4LPGJAvbMA1tn2zcRyqmYU5LC#z6MkghvGHLobLEdj1bgRLhS4LPGJAvbMA1tn2zcRyqmYU5LC"}, "issuer": "did:key:z6MkghvGHLobLEdj1bgRLhS4LPGJAvbMA1tn2zcRyqmYU5LC", "@context": ["https://www.w3.org/2018/credentials/v1"], "issuanceDate": "2024-04-26T20:20:15.256Z", "expirationDate": "2024-07-25T20:20:15.256Z", "credentialSubject": {"id": "did:pkh:eip155:1:0x59041d70deAEfe849A48E77e0b273DdD072eA9e4", "hash": "v0.0.0:Q14TlWbmR7/a+dCouG1C64GJ3DWo2N4CN+sjmeHQgPo=", "@context": [{"hash": "https://schema.org/Text", "provider": "https://schema.org/Text"}], "provider": "ClearTextTwitter#overlake_bio"}}}, "description": "ver. 0.2\n\n> Customizing human genetics to improve resilience and adaptability for thriving in space exploration and extraterrestrial habitats.\n\nUnlocking humanity's potential for space exploration and colonization through customizing or modifying human genetics to specifically enhance traits that make people more capable of surviving and thriving under the unique conditions of space, such as extreme radiation, microgravity, and isolation. This involves identifying or engineering genetic variations that improve resilience, health, and adaptability for space exploration and living on other planets.\n![](https://i.ibb.co.com/8M6fF7w/graphical-abstract.png)", "lastUpdated": 0, "projectTwitter": "overlake_bio"}, "recipient": "0x59041d70deAEfe849A48E77e0b273DdD072eA9e4"}}